India discovers world’s rarest blood group ‘CRIB’ in Bengaluru woman 11.08.2025
Scientists in India have identified an ultra rare blood group antigen called CRIB in a 38-year-old woman from Kolar, Karnataka. This groundbreaking discovery marks the first documentation of CRIB, a new antigen in the rare and complex Cromer blood group system. The patient’s blood was incompatible with all known donor units, including standard O positive blood, prompting months of research by the Rotary Bangalore TTK Blood Centre and the UK’s International Blood Group Reference Laboratory.
From a urologist’s perspective, this discovery holds great significance. Complex urologic surgeries often involve unpredictable blood loss and transfusions, and ultra rare blood groups like CRIB increase the risk of transfusion reactions. It underscores the necessity for close collaboration among urologists, hematologists, and transfusion specialists to develop targeted blood management strategies.
This finding also highlights the critical need to expand rare blood donor registries and improve screening in India and globally, to prevent life-threatening transfusion complications. The discovery showcases India’s advancement in transfusion medicine and reinforces the importance of innovation and awareness in rare blood groups and surgical blood safety.
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